Pepcid vs Prilosec OTC:Which is more popular?
In September 2026, Pepcid had more branded searches than Prilosec OTC among heartburn and digestive brands in the United States. Pepcid had about 246,000 branded searches, while Prilosec OTC had 135,000. Pepcid made up 25.4% of all heartburn and digestive brand searches we track, and Prilosec OTC accounted for 13.9%. When we asked ChatGPT and Google AI Overviews about heartburn and digestive brands, Pepcid and Prilosec OTC each appeared in three of the five answers. Pepcid was mentioned before Prilosec OTC in every answer.
Who do people search for more?
Pepcid, about 82% more searches than Prilosec OTC
Who does AI mention more?
Both were mentioned in 3 of 5 answers.
Who does AI recommend more?
Pepcid, named ahead of Prilosec OTC in every answer
Follow Pepcid vs Prilosec OTC and get free monthly updates on what changed
By continuing you'll get index updates and occasional product news from Brandwave. Unsubscribe any time. Privacy
Top heartburn and digestive brands in ChatGPT and Google AI Overviews
In three ChatGPT questions and two Google AI Overviews, Pepcid and Prilosec OTC were each mentioned in three out of five: in two of the three ChatGPT answers and in one of the two Google AI Overviews. Pepcid was listed before Prilosec OTC in every answer.
Most recommended by AI
Brands get a higher ranking if they are mentioned earlier in the answers.
Tums1st- Pepcid2nd
Prilosec OTC3rd
Pepto-Bismol4th- Gaviscon5th
Nexium6th
Mentioned by AI
Each dot is one answer, filled in when that answer mentions the brand.
- Tums5 of 5Named in 3 of 3 ChatGPT answersNamed in 2 of 2 Google answers
- Pepcid3 of 5Named in 2 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Prilosec OTC3 of 5Named in 2 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Pepto-Bismol2 of 5Named in 1 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Nexium1 of 5Named in 0 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Gaviscon1 of 5Named in 1 of 3 ChatGPT answersNamed in 0 of 2 Google answers
See every answer about heartburn and digestive brands
5 answers
Asked ChatGPT
“What's the best medicine for heartburn?”
Asked ChatGPT
“What's the best antacid?”
Asked ChatGPT
“What should I take for an upset stomach?”
Searched Google, AI Overview
“heartburn medicine”
Searched Google, AI Overview
“antacid”
- 1Tums
- 1
Brands are shown in the order each answer named them. The survey took place in United States on October 27, 2026.
Is Pepcid or Prilosec OTC more popular in search?
This chart shows how often people search Google for Pepcid and Prilosec OTC by name. Each line represents a brand's share of searches for all six heartburn and digestive brands we track, month by month, from searches in United States.
Share of searches by month for Pepcid, Prilosec OTC. The figures are in the table below the chart.
View monthly share of searches table
| Month | Pepto-Bismol | Pepcid | Prilosec OTC | Tums | Nexium | Gaviscon |
|---|---|---|---|---|---|---|
| Oct 2025 | 31.6% | 21.1% | 17.3% | 14.2% | 9.5% | 6.3% |
| Nov 2025 | 28.7% | 23.5% | 15.8% | 15.8% | 10.6% | 5.8% |
| Dec 2025 | 32.1% | 21.5% | 14.4% | 14.4% | 9.7% | 7.9% |
| Jan 2026 | 31.6% | 21.1% | 17.3% | 14.2% | 9.5% | 6.3% |
| Feb 2026 | 33.5% | 22.4% | 15% | 12.2% | 10.1% | 6.7% |
| Mar 2026 | 30.2% | 24.6% | 16.5% | 13.5% | 9.1% | 6.1% |
| Apr 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
| May 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
| Jun 2026 | 26.9% | 26.9% | 14.8% | 14.8% | 9.9% | 6.6% |
| Jul 2026 | 31.6% | 25.9% | 14.2% | 14.2% | 7.8% | 6.4% |
| Aug 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
| Sep 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
How has the Pepcid and Prilosec OTC comparison changed over the last 12 months?
3 findings
- Pepcid was ahead of Prilosec OTC in every measured month of the 12 months ending September 2026.
- Across the 12 months ending September 2026, Pepcid’s share of searches among heartburn and digestive brands in the United States moved from 21.1% to 25.4%, and its estimated monthly branded searches moved from 201K to 246K.
- Across the 12 months ending September 2026, Prilosec OTC’s share of searches among heartburn and digestive brands in the United States moved from 17.3% to 13.9%, and its estimated monthly branded searches moved from 165K to 135K.
How did search popularity change for United States heartburn and digestive brands in September 2026?
2 changes
Estimated monthly branded searches for Pepcid in the United States rose 22.4% over 12 measured months, from 201K to 246K in September 2026.
Estimated monthly branded searches for Prilosec OTC in the United States fell 18.2% over 12 measured months, from 165K to 135K in September 2026.
How are branded searches counted?
2 search terms
Brandwave collects information about searches that people make online using Pepcid’s and Prilosec OTC’s names. When viewed over time, estimated search volumes for these branded terms can be used to understand whether interest in the brands is growing, holding steady, or fading.
Pepcid
1 branded search term
- pepcid
Prilosec OTC
1 branded search term
- prilosec
Other head-to-heads among heartburn and digestive brands
Put your own brand in this comparison
Brandwave tracks your branded demand next to the rival you actually watch, with your campaigns, spend and outcomes on the same timeline.