Nexium vs Prilosec OTC:Which is more popular?
In September 2026, Prilosec OTC had more branded searches than Nexium among heartburn and digestive brands in the United States. Prilosec OTC had about 135,000 branded searches, while Nexium had 90,500. Prilosec OTC made up 13.9% of all heartburn and digestive brand searches we track, and Nexium accounted for 9.3%. When we asked ChatGPT and Google AI Overviews about heartburn and digestive brands, Prilosec OTC appeared in three of the five answers and Nexium in one. Prilosec OTC was mentioned before Nexium in every answer.
Who do people search for more?
Prilosec OTC, about 49% more searches than Nexium
Who does AI mention more?
Prilosec OTC, mentioned in 3 of 5 answers, Nexium in 1
Who does AI recommend more?
Prilosec OTC, named ahead of Nexium in every answer
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Top heartburn and digestive brands in ChatGPT and Google AI Overviews
In three ChatGPT questions and two Google AI Overviews, Prilosec OTC was mentioned in three out of five: in two of the three ChatGPT answers and in one of the two Google AI Overviews. Nexium was mentioned in one out of five: not in any of the three ChatGPT answers, but in one of the two Google AI Overviews. Prilosec OTC was listed before Nexium in every answer.
Most recommended by AI
Brands get a higher ranking if they are mentioned earlier in the answers.
Tums1st
Pepcid2nd- Prilosec OTC3rd
Pepto-Bismol4th- Gaviscon5th
Nexium6th
Mentioned by AI
Each dot is one answer, filled in when that answer mentions the brand.
- Tums5 of 5Named in 3 of 3 ChatGPT answersNamed in 2 of 2 Google answers
- Pepcid3 of 5Named in 2 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Prilosec OTC3 of 5Named in 2 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Pepto-Bismol2 of 5Named in 1 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Nexium1 of 5Named in 0 of 3 ChatGPT answersNamed in 1 of 2 Google answers
- Gaviscon1 of 5Named in 1 of 3 ChatGPT answersNamed in 0 of 2 Google answers
See every answer about heartburn and digestive brands
5 answers
Asked ChatGPT
“What's the best medicine for heartburn?”
Asked ChatGPT
“What's the best antacid?”
Asked ChatGPT
“What should I take for an upset stomach?”
Searched Google, AI Overview
“heartburn medicine”
Searched Google, AI Overview
“antacid”
- 1Tums
- 1
Brands are shown in the order each answer named them. The survey took place in United States on October 27, 2026.
Is Nexium or Prilosec OTC more popular in search?
This chart shows how often people search Google for Nexium and Prilosec OTC by name. Each line represents a brand's share of searches for all six heartburn and digestive brands we track, month by month, from searches in United States.
Share of searches by month for Prilosec OTC, Nexium. The figures are in the table below the chart.
View monthly share of searches table
| Month | Pepto-Bismol | Pepcid | Prilosec OTC | Tums | Nexium | Gaviscon |
|---|---|---|---|---|---|---|
| Oct 2025 | 31.6% | 21.1% | 17.3% | 14.2% | 9.5% | 6.3% |
| Nov 2025 | 28.7% | 23.5% | 15.8% | 15.8% | 10.6% | 5.8% |
| Dec 2025 | 32.1% | 21.5% | 14.4% | 14.4% | 9.7% | 7.9% |
| Jan 2026 | 31.6% | 21.1% | 17.3% | 14.2% | 9.5% | 6.3% |
| Feb 2026 | 33.5% | 22.4% | 15% | 12.2% | 10.1% | 6.7% |
| Mar 2026 | 30.2% | 24.6% | 16.5% | 13.5% | 9.1% | 6.1% |
| Apr 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
| May 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
| Jun 2026 | 26.9% | 26.9% | 14.8% | 14.8% | 9.9% | 6.6% |
| Jul 2026 | 31.6% | 25.9% | 14.2% | 14.2% | 7.8% | 6.4% |
| Aug 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
| Sep 2026 | 31.1% | 25.4% | 13.9% | 13.9% | 9.3% | 6.3% |
How has the Nexium and Prilosec OTC comparison changed over the last 12 months?
3 findings
- Prilosec OTC was ahead of Nexium in every measured month of the 12 months ending September 2026.
- Across the 12 months ending September 2026, Nexium’s share of searches among heartburn and digestive brands in the United States moved from 9.5% to 9.3%, and its estimated monthly branded searches held steady at 90.5K.
- Across the 12 months ending September 2026, Prilosec OTC’s share of searches among heartburn and digestive brands in the United States moved from 17.3% to 13.9%, and its estimated monthly branded searches moved from 165K to 135K.
How did search popularity change for United States heartburn and digestive brands in September 2026?
1 change
Estimated monthly branded searches for Prilosec OTC in the United States fell 18.2% over 12 measured months, from 165K to 135K in September 2026.
How are branded searches counted?
2 search terms
Brandwave collects information about searches that people make online using Nexium’s and Prilosec OTC’s names. When viewed over time, estimated search volumes for these branded terms can be used to understand whether interest in the brands is growing, holding steady, or fading.
Nexium
1 branded search term
- nexium
Prilosec OTC
1 branded search term
- prilosec
Other head-to-heads among heartburn and digestive brands
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